Gastric microbiota. The role of Helicobacter pylori and probiotics
The article presents literature data on the normal microbiota of the stomach and gastroduodenal disorders, the significance of non-helicobacter microbiota in the development and progression of chronic gastritis, and the interaction of non-helicobacter microbiota with Helicobacter pylori. The mechanisms of participation of gastric microbiota in carcinogenesis, the basics of the epigenetic action of H. pylori and non-helicobacter microbiota are described. Data on the possibilities of probiotic therapy in treatment of H. pylori infection are discussed. The authors also present data of their own research work on sequencing of gastric microbiota in children, depending on the presence of H. pylori. It has been found that H. pylori infection significantly depletes the composition of gastric microbiota, inhibiting the growth of other microbes. The article provides data about the effectiveness of the probiotic Bifiform in treatment of H. pylori infection in children with assessment of the immunological parameters of the blood and gastric mucosa. The immunomodulatory effect of the probiotic Bifiform has been demonstrated: a higher phagocytic activity, concentration of secretory immunoglobulin A, which was associated with an increase of the efficacy of eradication therapy and a decrease in side effects of antibiotics.
Key words: Helicobacter pylori, non-Helicobecter gastric microbiota, probiotics, Bifiform.
For citation: Kornienko E.A., Parolova N.I. Gastric microbiota. The role of Helicobacter pylori and probiotics. Vopr. det. dietol. (Pediatric Nutrition). 2019; 17(5): 33–46. (In Russian).