Iron metabolism in adolescent girls in Helicobacter pylori-associated chronic gastritis
The objective. To study interrelations of chronic Helicobacter pylori infection and iron-deficiency conditions in adolescent girls. Patients and methods. The examination included 94 girls aged 12–18 years who received treatment in a gastroenterological unit. Instrumental and clinical-laboratory methods of examination were used: fibrogastroscopy with biopsy, blood iron metabolism characteristics. Н.pylori was detected by morphological method and urease test. Statistical methods were used. Results. Iron deficiency among adolescent girls was found in 61.5% of cases, IDA – in 15.4%. Morphologically active gastritis was diagnosed in 83.0% of girls, Н.pylori was detected in 75.0% of the examined patients. In the group of infected girls, a decrease of hematocrit 39.3% vs 42.5% (p = 0.041) and average red blood cell volume – 97.8 fL vs 83.9 fL (p = 0.033) were noted as compared to the group without Н.pylori. In the group of patients with serum ferritin levels below 20 mkg/l, gastric mucosa colonization with Н.pylori was 100%, in case of the serum ferritin levels above 20 mkg/l colonization was detected in 63.8%, p = 0.007. The presence of mononuclear infiltration of gastric mucosa is associated with lower concentrations of serum iron 16.7 vs 22.8 mkmol/l, p = 0.02. Conclusion. The presence of Н.pylori-associated gastritis in adolescent girls is associated with low concentrations of serum iron and microcytosis.