Lactate and lactic acidosis: main pathogenetic mechanisms in the development of disease

Lactate (lactic acid) is a metabolic product of anaerobic glycolysis. Practically all cells with a high metabolic rate are capable of producing it. Lactate utilisation takes place predominantly in the liver and kidneys, to a lesser degree in the heart and skeletal
muscles. A transient increase of lactate levels occurs during intensive physical exercise and development of hyperlactatemia and stable lactic acidosis – in pathological conditions requiring intensification of the metabolic processes of aerobic and anaerobic glycolysis. As a rule, higher lactate levels are found in patients with urgent pathologies. But in medical practice a situation is possible when the patient’s state is not so critical but the lactate level is altered. Verification of the cause of hyperlactatemia might help a doctor to choose the correct tactics of the patient’s examination and management.
Key words: lactate, hyperlactatemia, lactic acidosis, metabolism, neoplastic and oncological processes
For citation: Bogdanova N.M., Novikova V.P., Khavkin A.I., Degtyareva N.S. Lactate and lactic acidosis: main pathogenetic mechanisms in the development of disease. Vopr. dietol. (Nutrition). 2020; 10(1): 45–52 (In Russian). DOI: 10.20953/2224-5448-2020-1-45-52