Continuous monitoring of postprandial glycaemia in the clinical practice of weight management in patients with metabolic syndrome

Objective. Development of a method of continuous monitoring of postprandial glycaemia for individual selection of a diet in the clinical practice of weight management in patients with metabolic syndrome.
Patients and methods. The study included 21 patients, of them 52.4% (11) women and 47.6% (10) men, aged 17 to 57 years (mean age 38 years). Depending on the body mass index (BMI) all patients were divided into 2 subgroups: group 1 – overweight patients (n = 11); 2 – obese patients (n = 10). In order to obtain evidence about postprandial glycaemic responses (PPGR) each participant wore a real-time glucose monitoring device. PPGR was recorded in the digital and graphic modes, which permitted to make statistical assessments and visual interpretation of the results. Later, based on the analysis of an individual variability of PPGR, individual data (body weight, height, age, presence of diseases, allergies, drug-associated load, etc.), all patients received an individual diet plan for a week. The MAGE index was used for objective assessment of diet effectiveness. The paired sample T criterion was used for difference assessment.
Results. The results of our study have demonstrated a high across-subject variability of PPGR to the same food product. A week after using a diet with individually selected «good» products weight loss was obtained in all patients. In our study, all patients who followed their diet plan had a lower MAGE index. Therefore, the diet offered to the patients significantly decreased the average level of glucose fluctuation.
Conclusion. Assessment of the variability of postprandial glycaemic responses with the use of continuous glucose monitoring system has good prospects for finding predictors of weight management in patients with metabolic syndrome. 
Key words: individual diet, weight management, metabolic syndrome, monitoring of glycaemia,
postprandial glycaemic response, MAGE.
For citation: Bazylev V.V., Babkina I.А., Solovev V.V., Solovev K.V. Continuous monitoring of postprandial glycaemia in the clinical practice of weight management in patients with metabolic syndrome. Vopr. dietol. (Nutrition). 2019; 9(3): 5–15. (In Russian).
DOI: 10.20953/2224-5448-2019-3-5-15


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