Neurodegenerative diseases are characterised by progressing and irreversible atrophy of neurons in different parts of the central nervous system. Selective damage of CNS structures in neurodegenerative diseases is conditioned by influence of genetic factors and pathogenic factors of the environment on specific metabolic and physiological processes in neurons. Incorrect epigenetic programming and disordered functioning of neurons might be caused by imbalanced nutrition and imbalance of symbiotic microbiota of the digestive tract. Correction of human microbiota and nutrition has good prospects as prevention of neurodegenerative diseases due to compensation of chronic exhaustion in the brain tissues of adaptive reserves of nutrients, co-factors, signal and other molecules involved in energy metabolism and epigenetic processes in nerve cells, and in consequence, in the synthesis and functioning of related neurotransmitters and their receptors.
Alzheimer's and Parkinson's diseases, imbalance of nutrition and symbiotic gut microbiota, neurodegenerative diseases, prevention of neurodegenerative disorders, functional nutritional and microbial ingredients, epigenomic programming.
Danilov A.B., Prishchepa A.V. A key role of nutrition and gut microbiota in the development of neurodegenerative diseases. Vopr. dietol. (Nutrition). 2016; 6(4): 36–46.