The article discusses the role of genetic factors in the development of metabolic syndrome. As is shown, gene mutations are unequally manifested in different populations, and their occurrence often depends on the gender, age and ethnic group of carriers. Each of key components of metabolic syndrome – obesity, dyslipidemia, hyperglycaemia and high blood pressure, – has genetic predisposition, for which main candidate genes have been specified. Such predisposition might lead to the development of metabolic syndrome or accelerate its development. New technologies aimed at predicting risk factors of development of metabolic syndrome based on molecular genetic tests will permit to early diagnose patients referring to a high risk group for its development and to take preventive measures at the preclinical stage, to elaborate personalized approaches to treatment and prevention of metabolic syndrome.
candidate genes, metabolic syndrome, molecular genetic testing.
Sharafetdinov Kh.Kh., Yudochkin A.V., Plotnikova O.A. The role of genetic factors in the development of metabolic syndrome. Vopr. dietol. (Nutrition). 2016; 6(4): 29–35.