A characteristic of nutritional status in children with chronic hepatitis C against the background of combined antiviral therapy

The objective. To study the dynamics of the nutritional status in children with chronic hepatitis C against the background of a course of combined antiviral therapy (AVT).

Patients and methods. The study included 98 children (52 girls) with CHC who were observed at the department of paediatric gastroenterology, hepatology and dietetics of FRC of Nutrition and Biotechnology. In all children, prior to the beginning of therapy and after its termination anthropometric parameters were assessed (body weight, height), body mass index (BMI), height and BMI Z-score were calculated, and body composition was examined by the method of bioimpedance analysis.

Results. Combined regimen of antiviral therapy in children with CHC results in a significant decrease of body weight, BMI, BMI and height Z-score; body composition assessment shows lower values of fat, muscle mass, proteins, mineral substances, total body water. After termination of therapy normal BW was preserved in 48% of children (47/98), overweight in 8% (8/98), obesity in 1% (1/98), BW deficiency was noted in 43% of children (42/98). Individual assessment of body composition found fat mass deficiency fat mass deficiency before treatment in 30% of children (20/68), after termination – in 43% (29/68). MSM deficiency was found in 18% of children (12/68), after the course of therapy – in 34% (23/68).

Conclusion. The results of the study have shown that children, who receive a course of AVT, require monitoring of their nutritional status. If signs of nutritional deficiency are found, it should be corrected in due time using both nutritional support and food supplements.

Key words: children, nutritional status, antiviral therapy, body composition, chronic hepatitis C.

For citation: Matinyan I.A., Sentsova T.B., Strokova T.V., Pavlovskaya E.V., Kaganov B.S. A characteristic of nutritional status in children with chronic hepatitis C against the background of combined antiviral therapy. Vopr. dietol. (Nutrition). 2016; 6(4): 5–9. (In Russian).
DOI: 10.20953/2224-5448-2016-4-5-9

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