Role of screening for anti-HIV antibodies in patients treated in large multidisciplinary hospitals
Objective. To evaluate the significance of yearly dynamics of HIV detection rates in patients from multidisciplinary hospitals as a parameter for monitoring of the epidemiological situation and to identify the institutions with the highest risk of occupational HIV transmission among medical staff employed in various hospital units.
Materials and methods. We analyzed HIV detection rates in 186,314 adult patients treated in a large multidisciplinary hospital between 2004 and 2015. We used ELISA assays allowing the detection of both HIV antigens and antibodies against it. The results of ELISA testing were confirmed by immunoblotting. Binomial confidence intervals were calculated using the exact Clopper-Pearson method. The multiannual dynamics of the analyzed parameters was evaluated by calculating the trend values using the least square method.
Results. Yearly dynamics of HIV detection rates in patients of a multidisciplinary hospital can be considered as an important quantitative parameter for epidemiological monitoring of HIV infection. The highest risk of occupational HIV transmission was observed in units receiving emergency patients, including ophthalmological, maxillofacial surgery, and ENT units.
Conclusion. The epidemiological monitoring system requires permanent improvement and search for additional monitoring parameters, especially quantitative ones, which are actively being studied now.
Key words: HIV infection, patients of a multidisciplinary hospital, epidemiological monitoring system.
For citation: Kudryavtseva E.N., Semenenko T.A., Godkov M.A., Ershova O.N., Korabelnikova M.I., Ivanova M.Yu., Kuzin S.N. Role of screening for anti-HIV
antibodies in patients treated in large multidisciplinary hospitals. Infekc. bolezni (Infectious diseases). 2019; 17(2): 5–11. (In Russian).