Specificities of pathogenetic therapy in patients with foodborne infections and concomitant cardiovascular pathologies
The objective. To evaluate the effectiveness of pathogenetic rehydration therapy for foodborne infections (FIs) in their combination with chronic cardiovascular pathologies and its effect on the indices of hemostasis and the endothelium. Patients and methods. The state of hemostasis was examined in 90 patients with FIs and concomitant cardiovascular pathologies. The average age of the patients was 67.45 ± 14.52 years, among them 44 males and 46 females. The patients were examined at admission to hospital prior to treatment and in the early convalescence period (at days 1–2 and 6–7 of hospitalization, respectively). The control group to evaluate the physiological level of the indices of hemostasis included 20 practical y healthy individuals. Results. Against the background of adequate in volume and duration rehydration therapy, normalization of the levels of D-dimer (0.83 ± 0.15 ng/ml) and thrombomodulin (3.56 ± 1.06 ng/ml) were obtained, which by the moment of discharge from hospital did not have significant differences from the values of the control group (0.46 ± 0.05 ng/ml and 3.28 ± 0.10 ng/ml, respectively, p >- 0.05), thrombocyte aggregation had a tendency to restoration (32.16 ± 2.32 and 47.8 ± 3.7%, respectively). In patients with FIs combined who received inadequate rehydration therapy no positive dynamics of the above values was found. Conslusion. In patients with FIs combined with arterial hypertension and ischaemic heart disease, adequate rehydration therapy contributes to a fuller restoration of the indices of hemostasis, including endothelial factors, faster improvement of wellbeing, reduces the terms of disease and hospitalization, and prevents development of complications.