Clinical Practice in Pediatrics

Assessment of the effective doses of nasal sprays using a volumetric simulation model

The completeness of drug precipitation in the nasal cavity is a key factor determining the effectiveness of drug delivery by nasal spray to the nasal mucosa. To assess it, we used a volumetric simulation model composed of a vertical tube simulating the nasal passage and a lid covering the ‘entrance into the nasopharynx.’ Filter paper impregnated with Dragendorf reagent was used to assess drug precipitation. Using this model, we evaluated distribution of the delivered dose, i.e. effective (deposited on the mucous membrane) and ineffective (drained into the nasopharynx) portions of the dose. Comparative analysis of weight fractions of effective dose performed for 9 different nasal sprays using Mann–Whitney U test showed significant differences for most of the pairs of nasal sprays. The maximum complete precipitation of the spray on the nasal mucosa was demonstrated by Vicks Sinex 89.3%), Afrin Extro (82.6%), and Nesopin (79,4%). Visualization of spray irrigation zones in the model showed that
the most homogenous irrigation was ensured by Vicks Sinex and Nesopin. Our results provide additional information for doctors and pharmacists for choosing an optimal nasal spray containing oxymetazoline in terms of the efficacy of its delivery to the nasal mucosa.
Key words: oxymetazoline, metered nasal spray, volumetric simulation model, effective delivery.

For citation: Yankova V.G., Gribanova S.V., Udyanskaya I.L., Grigoreva V.Yu., Karpova P.A., Kurzaeva A.G., Slonskaya T.K. Assessment of the effective doses of nasal sprays using a volumetric simulation model. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2019; 14(4): 94–98. (In Russian).

DOI: 10.20953/1817-7646-2019-4-94-98