Clinical Practice in Pediatrics

Current concepts of intestinal dysbiosis as a risk factor for atopic dermatitis in children

Recently, the problem of atopic dermatitis has been attracting attention of many healthcare professionals, since the prevalence of the disease is steadily growing. The composition of intestinal microbiota is believed to be a significant risk factor for atopic dermatitis. The formation of healthy intestinal microflora is affect by multiple factors, including pathological course of pregnancy
and childbirth, cesarean section, premature birth, late start of breastfeeding, bottle feeding during the first 6 months of life, suboptimal nutrition of infants, and antibacterial therapy. The development of molecular genetic methods has expanded our knowledge in the spectrum of microorganisms of the intestinal microbiota. The use of probiotics has a positive effect on the intestinal microbiota, which allows their use for the prevention and treatment of atopic dermatitis. In this review, we analyzed currently available
Russian and foreign studies evaluating intestinal microbiota using contemporary methods and assessing risk factors for intestinal dysbiosis, development of allergic diseases in infants, and the impact of probiotics on the course atopic dermatitis.
Key words: intestinal microbiota, children, atopic dermatitis, caesarean section, breastfeeding, antibacterial therapy, 16S sequencing.

For citation: Yudina Yu.V., Korsunskiy A.A., Aminova A.I., Eremeeva A.V., Kolotilina A.I., Abdullaeva G.D., Prodeus A.P. Current concepts of intestinal dysbiosis as a risk factor for atopic dermatitis in children. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2019; 14(4): 44–50. (In Russian).
DOI: 10.20953/1817-7646-2019-4-44-50