Clinical Practice in Pediatrics

Efficacy of a homeopathic drug in combination treatment of acute obstructive laryngitis in children

Acute obstructive laryngitis (AOL) is a quite common disease of children, which often requires emergency care. There is still some controversy regarding the optimal type, dose, and route of administration of glucocorticoids to eliminate the symptoms of AOL. The effectiveness of therapy that can increase their efficacy is not sufficiently studied.
Objective: to assess the efficacy and safety of a homeopathic drug Meditonsin® in combination with inhaled and systemic corticosteroids in children with AOL treated in inpatient settings.
Patients and methods. A total of 60 children aged between 1 and 6 years hospitalized with the diagnosis of AOL were included into this open, prospective, randomized study. All children received one inhalation of budesonide at a dose of 1 mg; if this was ineffective, patients were given dexamethasone at a dose of 0.5 mg/kg intramuscularly once or more. Inhalations with adrenaline
were not used. Patients were randomized by envelopes into two parallel groups. Children in the experimental group additionally received homeopathic drug Meditonsin® according to package insert during 6 days. The severity of symptoms was estimated by score (mild, moderate, and severe symptoms).
Results. One inhalation of corticosteroids at a dose of 1 mg was effective (eliminated laryngeal stenosis) in 68.3% (95% CI; 55.0–79.7%) of children aged between 1 and 6 years with grade I–II AOL. The tactics with one inhalation of budesonide at a dose of 1 mg with subsequent intramuscular injection of dexamethasone at a dose of 0.5 mg/kg (if inhalation gave no effect) was effective in 86.7% of patients (95% CI; 75.40%–94.1%) within 24 hours. None of the children receiving Meditonsin® required administration of corticosteroids; more than two-thirds of them (70%) had no symptoms of acute respiratory viral infections (rhinitis, cough, pharyngeal hyperemia) by day 6 of therapy. In the control group, 13.3% of patients required corticosteroids 24 hours following the initiation of treatment, while symptoms of acute respiratory viral infections were absent only in 26.7% of children (р = 0.002).
Conclusion. Therapy with Meditonsin® can reduce the frequency of corticosteroid administration 24 hours following the initiation of AOL treatment and decreases the frequency of symptoms (cough, rhinitis, pharyngeal hyperemia) by 43% (95% CI 21%–66%) by day 6 (HR –0.41; 95% CI –1,48; –0,31; OR 0.16; 95% CI 0,05; 0,48), thereby facilitating the recovery.
Key words: children, acute obstructive laryngitis, treatment, budesonide, dexamethasone, Meditonsin®, Aconitum, Atropinum sulfuricum, Mercurius cyanatus.

For citation: Meskina E.R., Khadisova M.K., Tselipanova E.E. Efficacy of a homeopathic drug in combination treatment of acute obstructive laryngitis in children. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2019; 14(4): 36–43. (In Russian).

DOI: 10.20953/1817-7646-2019-4-36-43

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