Clinical Practice in Pediatrics

Capability of a new formula for enteral nutrition enriched with pre- and probiotics, in the correction of malnutrition and maintaining natural immune defense of the children

The gastrointestinal system plays a central role in immune system homeostasis. Gut-associated lymphoid tissue (GALT) is theprominent part of mucosal-associated lymphoid tissue (MALT) that support natural immune defense of the children. GALT interacts strictly with gastrointestinal functions by increasing intestinal permeability or orientating the immune response and can provoke damage of the intestinal mucosa, such as in critical conditions or food allergy. The human intestine contains non pathologic bacteria which provides a specific immune defense. Аlterations in this symbiotic relationship may occur during stress, criticalillness, prolonged GI tract starvation, exogenous antibiotics. The probiotics and prebiotics play an important role in maintaining normal microbiota composition, metabolism and immunity. Some studies have suggested a beneficial effect of synbiotics in the management of GI and critical conditions in children. Clinutren® Junior with pre- and probiotics has been
clinically tested in children in the Paediatric ICU and chronic GI disease and shown to be safe and well tolerated.
Keywords: intensive care, GALT, probiotics, prebiotics, synbiotics, malnutrition, absorption disorders, oral nutritional support, enteral nutritional support.
Publisher's imprint: L.N.Berestennikova. Capability of a new formula for enteral nutrition enriched with pre- and probiotics, in the correction of malnutrition and maintaining natural immune defense of the children. Clinical Practice in Pediatrics. 2015;10(2):67-77.
Received: 19.03.2015

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