Clinical Practice in Pediatrics

Correction of the elastase enzyme system and its inhibitors in premature newborns with nosocomial pneumonia at artificial lung ventilation

In the study of the enzyme system of elastase and its inhibitors in 160 premature newborns the indices of the conditional norm were  worked  out,  their  dependence  from  the  gestational  age  of  the  patient  was  established.  Characteristic  changes  of  the enzyme system of elastase were found for premature infants suffering respiratory failure syndrome and nosocomial pneumonia, who were receiving artificial lung ventilation. In 83 premature infants with nosocomial pneumonia the effect of aprotinin on the enzyme system and clinical manifestations of pneumonia were studied.