Clinical Practice in Pediatrics

The first transplantation of the small intestine in russian clinical practice

The small intestine insufficiency syndrome is a fatal condition. The only conservative method of prolongation of the patients’ lives is considered to be total parenteral nutrition, whose possibilities are limited in both time and efficacy. Transplantation of the small intestine should be regarded as the most physiological method of replacement therapy, however, as compared with transplantation of other solid organs the number of transplantations of the small intestines in the world practice is not great. In Russia,  this  method  has  not  been  used  in  medical  practice  by  now.  On  May  2006,  in  the  B.V.Petrovsky  Russian  Scientific Center of Surgery, Russian academy of Medical Sciences, a 16-month infant, who received total parenteral nutrition due to the surgical  removal  of  the  whole  small  intestine,  a  fragment  of  the  small  intestine  was  transplanted  from  a  live  related  donor (father). The post-operative period was smooth, the transplant functions normally, the baby is fed totally by mouth, quickly gains body weight. A 4-component protocol of immunosuppressive therapy was used, no signs of rejection are observed.